Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing sp1 glycosylation
Thus, endothelial OS is both a driver and consequence of HTN, making it a pivotal target for interventions aimed at breaking the cycle of vascular dysfunction
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La posologie de Vitamine B12 Gerda devra aussi tre adapte en fonction de l'intensit de la carence : Une posologie par voie orale de 4 000 g (durant les 2 premiers trimestres de la grossesse) et 5 000 g (durant le 3me trimestre et l'allaitement) tous les 15 jours chez les femmes enceintes ou allaitantes ayant un apport en vitamine B12 insuffisant
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